Plenty of trinkets don't need to be held constantly to benefit from their effects, so dropping them when they aren't needed is often advisable.Holding NO! when taking a hit will re-roll Tainted Eden's active item into a passive item, which may or may not be desired.If Book of Virtues is acquired from a Library, it cannot be re-rolled away due to how Book of Virtues is the only passive item in the Library item pool. The Library can be powerful for Tainted Eden.Cards, Runes, and Pills that aren't useful at the moment but may be useful later should be left or dropped on the ground so as to not lose them if a re-roll occurs.Carrying around a Trinket, even a useless one, carries the opportunity of re-rolling it into a very good one, such as Cancer or Cracked Crown and so on.Focusing heavily on Devil Room items and not relying on Red Heart Containers in the first place is a viable strategy if plentiful Soul Hearts are acquired.Active Devil Room Items are also very useful to keep around, as which can be re-rolled into Damocles or Guppy's Paw. ![]() ![]() However, while Secret Room passive items are very risky, active items are instead very useful to keep around, as they are generally powerful, and they can be re-rolled into R Key or Death Certificate. and TMTRAINER, both of which are extremely detrimental to almost any run. Passive Secret Room items can offer powerful synergies, but run the risk of re-rolling into Missing No.It is also the only way to obtain Birthright. Remember to check Shop, as which may provide discounted items, and passive items in Shop item pool may be re-rolled into great items like Blue Map or Black Candle, whose effects last for the current floor.In particular, Angel Room items and Planetarium items are high-quality on average. ![]()
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